General Information

  • ID:  hor005629
  • Uniprot ID:  Q9IAU2
  • Protein name:  GnRH-associated peptide I
  • Gene name:  NA
  • Organism:  Rana dybowskii (Dybovsky's frog) (Korean brown frog)
  • Family:  GnRH family
  • Source:  Animal
  • Expression:  Expressed in forebrain but not in testis, ovary, kidney and liver.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Rana (subgenus), Rana (genus), Ranidae (family), Ranoidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity; GO:0005183 gonadotropin hormone-releasing hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

  • Sequence:  EVEGLQESYSEVPNEVSFTDPQHFERSIPQNRISLVREALMNWLEGENT
  • Length:  49(38-86)
  • Propeptide:  MSRHVTVVLLLAVVLLLSSHMSHGQHWSYGLWPGGKREVEGLQESYSEVPNEVSFTDPQHFERSIPQNRISLVREALMNWLEGENTRKKI
  • Signal peptide:  MSRHVTVVLLLAVVLLLSSHMSHG
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Stimulates the secretion of gonadotropins.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-V9QF69-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005629_AF2.pdbhor005629_ESM.pdb

Physical Information

Mass: 656252 Formula: C248H380N68O85S
Absent amino acids: CK Common amino acids: E
pI: 3.96 Basic residues: 4
Polar residues: 14 Hydrophobic residues: 14
Hydrophobicity: -79.8 Boman Index: -12488
Half-Life: 1 hour Half-Life Yeast: 30 min
Half-Life E.Coli: >10 hour Aliphatic Index 73.47
Instability Index: 4342.65 Extinction Coefficient cystines: 6990
Absorbance 280nm: 145.63

Literature

  • PubMed ID:  11026571
  • Title:  Molecular cloning, distribution and pharmacological characterization of a novel gonadotropin-releasing hormone (Trp8 GnRH) in frog brain.